Breakinduced replication (BIR) is a nonreciprocal recombinationdependent replication process that is an effective mechanism to repair a broken chromosome We review key roles played by BIR in maintaining genome integrity, including restarting DNA replication at broken replication forks and maintaining telomeres in the absence of telomerase DNA strand breakinduced replication fork collapse stimulates formation of Ccircle and Coverhang To examine a potential relationship between replicationblocking and formation of Ccircle and Coverhang, U2OS cells were treated with agents that result in replicationRepeat expansions breakinduced replication (BIR), an HR pathway that is responsible for the repair of oneended DSBs BIR begins with DNA end resection followed by Rad51mediated strand invasion into a homologous DNA region 5 BIR represents an unusual DNA synthesis mechanism that can continue for hundreds of kilobases, is carried
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Break induced replication repair
Break induced replication repair- Breakinduced replication (BIR) is a DNA doublestrand break repair pathway that leads to genomic instabilities similar to those observed in cancer BIR proceeds byBreakinduced replication (BIR) is a pathway that repairs oneended doublestrand breaks (DSBs) For decades, yeast model systems offered the only opportunities to study eukaryotic BIR
Mechanisms Restraining Break Induced Replication At Two Ended Dna Double Strand Breaks The Embo Journal
Breakinduced replication (BIR) is a pathway that repairs oneended doublestrand breaks (DSBs) For decades, yeast model systems offered the only opportunities to study eukaryotic BIR These studies described an unusual mode of BIR synthesis that is carried out by a migrating bubble and shows conse Both of the yeast pathways also require Pol32, a subunit of DNA polymerase δ critical for breakinduced DNA replication (BIR) (Lydeard et al, 07) Recent studies in human cells further revealed that ALT is a replication stressassociated and BIRrelated process However, DSBs that arise by replication fork collapse or by erosion of uncapped telomeres have only one free end and are thought to repair by strand invasion into a homologous duplex DNA followed by replication to the chromosome end (breakinduced replication, BIR)
BreakInduced Replication in E coli Even before elucidation of T4 RDR, connections between replication and recombination in bacteria had been suspected Lederberg proposed a breakcopy model of recombination, whereby a broken chromosome would stimulate replication by Cell wall protein variation, break‐induced replication, and subtelomere dynamics in Candida glabrata Zhuwei Xu Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD, USA Search Breakinduced replication (BIR) is the pathway of homologous recombination (HR) conserved from phages to eukaryotes that serves to repair DNA breaks that have only one end BIR contributes to the repair of broken replication forks and allows telomere lengthening in the absence of telomerase
One way of repairing a DNA break is through invasion of an end into a homologous, intact duplex, which can set up a replication fork However, this work shows thatBreakinduced replication (BIR) is an important pathway specializing in repair of oneended doublestrand DNA breaks (DSBs) This type of DSB break typically arises at collapsed replication forks or at eroded telomeresThe DSBs were repaired by POLD3/POLD4dependent breakinduced replication (BIR), resulting in fragile telomeres containing conservatively replicated DNA BIR also promoted fragile telomere formation in cells with FokIinduced telomeric DSBs and in alternative lengthening of telomeres (ALT) cells, which have spontaneous telomeric damage
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Stalled replication forks are restarted through two main pathways 24 The 53BP1dependent cleavagefree pathway acts at the early stage of In this report, we demonstrate that breakinduced replication (BIR) is used predominantly over SSA in mammalian cells for mediating RMD, especially when repeats are far apart We show that SSA becomes inefficient in mammalian cells when the distance between the DSBs and the repeats is increased to the 1–2 kb range, while BIRmediated RMD (BIR "Breakinduced replication" (BIR) is considered as one way to repair DNA doublestrand breaks (DSBs) BIR is defined as replication of the proximal breakends up to the end of the broken chromosome using an undamaged (homologous) doublestranded template and mimicking a nonreciprocal translocation
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Breakinduced replication (BIR) is a pathway that repairs oneended doublestrand breaks (DSBs) For decades, yeast model systems offeredBreakinduced replication (BIR) is an important pathway specializing in repair of oneended doublestrand DNA breaks (DSBs) This type of DSB break typically arises at collapsed replication forks or at eroded telomeres BreakInduced Replication A more specific model for restarting replication at collapsed (broken) replication forks, BIR, has been developed for yeast, and a similar mechanism was proposed to explain telomere maintenance in yeast and human cell lines that have lost telomerase activity (reviewed in)
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Read chapter Breakinduced replication A review and an example in budding yeast There has been a sea change in how we view genetic recombination When gDouble Strand BreakInduced Replication The repair of broken chromosomes by homologous recombination may occur in several ways (See Introduction) If both ends at the break have homology to sequences on an unbroken chromosome that can serve as a template, then repair may proceed by gene conversion Singleended DSBs are repaired by breakinduced replication (BIR), which involves extensive and mutagenic DNA synthesis spanning up to hundreds of kilobases It remains unknown how mutagenic BIR is suppressed at twoended DSBs
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Breakinduced replication (BIR) is a mechanism used to heal oneended DNA doublestrand breaks, such as those formed at collapsed replication forks or eroded telomeres Instead of utilizing a canonical replication fork, BIR is driven by a migrating Dloop and is associated with a high frequency of mutagenesis//wwwibiologyorg/geneticsandgeneregulation/mechanismsdnarepair/#part1A stepbystep description of BreakInduced Replication when restarting DN In human cancers, oncogene activation interferes with DNA replication, leading to DNA replication stress and DNA doublestrand breaks (DSBs) Costantino et al (p 1, published online 5 December) identified two subunits of DNA polymerase delta, POL3 and POL4, as critical for survival of DNA replication stress in human cells Both subunits were required for breakinduced replication
Plos Genetics Strand Break Induced Replication Fork Collapse Leads To C Circles C Overhangs And Telomeric Recombination
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Breakinduced replication (BIR) repairs oneended doublestrand breaks in DNA similar to those formed by replication collapse or telomere erosion, and itOne such pathway is breakinduced replication (BIR), which repairs primarily oneended DSBs, similar to those formed by collapsed replication forks or telomere erosion Breakinduced replication (BIR) is a specialized homologousrecombination pathway for DNA doublestrand break (DSB) repair, which often induces genome instability In this study, we establish EGFPbased recombination reporters to systematically study BIR in
Rad51 Independent Break Induced Replication To Repair A Broken Chromosome Depends On A Distant Enhancer Site
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BreakInduced Replication The Where, The Why, and The How J Kramara,2 B Osia,2 and A Malkova1,* Breakinduced replication (BIR) is a pathway that repairs oneended doublestrand breaks (DSBs) For decades, yeast model systems offered the only opportunities to study eukaryotic BIR These studies described an unusual mode Breakinduced replication (BIR) is a nonreciprocal recombinationdependent replication process that is an effective mechanism to repair a broken chromosome We review key roles played by BIR in maintaining genome integrity, including restarting DNA replication at broken replication forks and maintaining telomeres in the absence of telomeraseMammalian RAD52 Functions in BreakInduced Replication Repair of Collapsed DNA Replication Forks Human cancers are characterized by the presence of oncogeneinduced DNA replication stress (DRS), making them dependent on repair pathways such as breakinduced replication (BIR) for damaged DNA replication forks
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Break Induced Replication Plays A Prominent Role In Long Range Repeat Mediated Deletion The Embo Journal
Based on the study in yeast, a DSB repair pathway called breakinduced replication (BIR) is believed to be a major source of replicative GCR Since the mechanistic study of BIR has been mostly carried out in yeast, a model system to study BIR mechanism and its role in suppressing genome instability in mammalian cells is highly in demand Breakinduced replication (BIR) is one of the DSB repair pathways that is highly prone to genetic instability 1, 2, 3 BIR proceeds by invasion of one broken end into a homologous DNA sequence The DSBs were repaired by POLD3/POLD4dependent breakinduced replication (BIR), resulting in fragile telomeres containing conservatively replicated DNA BIR also promoted fragile telomere formation in cells with FokIinduced telomeric DSBs and in alternative lengthening of telomeres (ALT) cells, which have spontaneous telomeric damage
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Breakinduced replication (BIR) refers to recombinationdependent DNA synthesis initiated from one end of a DNA doublestrand break and can extend for more than 100 kb BIR initiates by Rad51catalyzed strand invasion, but the mechanism for DNA synthesis is not known Here, we used BrdU incorporation to track DNA synthesis during BIR and found that the newly Breakinduced replication (BIR) is a specialized homologousrecombination pathway for DNA doublestrand break (DSB) repair, which often induces genome instability In this study, we establish EGFPbased recombination reporters to systematically study BIR in mammalian cells and demonstrate an important role of human PIF1 helicase in promoting BIR In this report, we demonstrate that breakinduced replication (BIR) is used predominantly over SSA in mammalian cells for mediating RMD, especially when repeats are far apart We show that SSA becomes inefficient in mammalian cells when the distance between the DSBs and the repeats is increased to the 12 kb range, while BIRmediated RMD (BIR
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Dna Polymerase Delta Synthesizes Both Strands During Break Induced Replication Sciencedirect
Breakinduced replication (BIR) refers to recombinationdependent DNA synthesis initiated from one end of a DNA doublestrand break and can extend for more than 100 kb BIR initiates by Rad51catalyzed strand invasion, but the mechanism for DNA synthesis is not known Here, we used BrdU incorporation to track DNAIn budding yeast, oneended DNA doublestrand breaks (DSBs) and damaged replication forks are repaired by breakinduced replication (BIR), a homologous recombination pathway that requires the Pol32 subunit of DNA polymerase delta DNA replication stress is prevalent in cancer, but BIR has not been characterized in mammals Breakinduced replication (BIR) is a unique cellular process that mimics normal DNA replication in its processivity, rate, and capacity to duplicate hundreds of kilobases, but is initiated at doublestrand breaks (DSBs) rather than at replication origins
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Trf1 Averts Chromatin Remodelling Recombination And Replication Dependent Break Induced Replication At Mouse Telomeres Elife
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