Breakinduced replication (BIR) is a nonreciprocal recombinationdependent replication process that is an effective mechanism to repair a broken chromosome We review key roles played by BIR in maintaining genome integrity, including restarting DNA replication at broken replication forks and maintaining telomeres in the absence of telomerase DNA strand breakinduced replication fork collapse stimulates formation of Ccircle and Coverhang To examine a potential relationship between replicationblocking and formation of Ccircle and Coverhang, U2OS cells were treated with agents that result in replicationRepeat expansions breakinduced replication (BIR), an HR pathway that is responsible for the repair of oneended DSBs BIR begins with DNA end resection followed by Rad51mediated strand invasion into a homologous DNA region 5 BIR represents an unusual DNA synthesis mechanism that can continue for hundreds of kilobases, is carried
Break Induced Replication Is Highly Inaccurate
